The Science Behind Our Supplements

Supplementing With Fisetin


Supplementing with fisetin is becoming more popular, thanks to recent studies suggesting that the senolytic antioxidant is very beneficial to health. A particular suggestion that has turned heads is that fisetin has powerful senolytic qualities that may suppress damaged DNA from replicating. Fisetin is chiefly found in strawberries, as well as a couple of fruits and veggies. 


What Is Fisetin?


Fisetin is a flavonoid mostly found in fruits and vegetables, for example, cucumber, apple, and strawberry. The senolytic antioxidant, according to Frontiers In Chemistry, has shown the ability to serve as an anti-inflammatory, chemotherapeutic, chemopreventive & senotherapeutic agent. 

Like earlier said, the limelight is on fisetin as a result of its senolytic qualities. A senolytic refers to a small class of molecules that causes death to senescent/deteriorating cells. The implication is that senolytic is considered a crucial aid to healthy old age.


Foods Containing Fisetin


We can agree that fisetin is found only in fruits and vegetables, and for a good reason. It is, in other words, a yellow pigment found in plants. So, you see. By eating any of the following plants, you help yourself to some fisetin:

  • strawberries
  • apples
  • cucumbers
  • lotus root
  • kiwi
  • onions
  • mangoes
  • persimmons
  • kale
  • peach

6 Benefits Of Supplementing With Fisetin


Fisetin supplementation may not be essential since it is widely available. I don’t think there’s any dieter that doesn’t eat fruits and veggies. However, eating fruits does not mean that you can’t supplement with fisetin, especially if you’re becoming a senior. Let us look at the benefits of fisetin, whether when taken as a supplement or eaten in fruits and vegetables. Here we go.


Functions as an Antioxidant


Antioxidants are (arguably, to a certain extent) the best beneficial compounds you’ll find in foods. These compounds are known for several body functions, ranging from cardiovascular disease prevention and treatment to mental health improvements. They are also known for their immune function fortification roles, but their most prominent function remains cancer prevention and treatment.

Cancers are chiefly caused by free radicals' activities, which are disfigured cells living in the body, and this is where antioxidants come in. Antioxidants, such as flavonoids found in fisetin, help inhibit the growth and development of these cells, while some other antioxidants foster apoptosis, which is instant death of harmful cells. 

Fortunately, fisetin is rich in antioxidants, so continuous consumption can only enhance overall body, mental and cardiovascular health.


Boasts Senolytic Activity


As earlier defined, senolytic is a group of small molecules that suppresses the multiplication of damaged DNA. By so doing, it helps limit the development of age-related diseases and improves the effects of aging. Now, there are several forms of flavonoids, all of which are senolytic. According to research, fisetin happened to be the most effective when tested alongside others like curcumin, rutin, and luteolin.

The impacts of this capability are often underrated. With such a powerful anti-aging property in fisetin, you can enjoy healthy living in your old age. This means preventing neurodegenerative diseases, maintaining fine skin, and better coordination even in old age. That’s a host of impressive contributions to your health.


Possesses Anti-Cancer Properties


We already know that fisetin contains antioxidants, so sensible suggestions are associating it with cancer treatment. In addition to these compounds, fisetin boasts anti-proliferative qualities against cancer, meaning that it helps suppress the growth or spread of a tumor and reduce angiogenesis, which is the development of new blood vessels. Studies on this are not yet established, but there’s one worth mentioning.

A 2019 study divided 30 women into two groups. One of the groups was treated with conventional cancer treatments and regular consumption of fisetin foods, while the other group used just conventional cancer treatments. After two months, the participants of the first group were responding faster to treatments than the others. However, this result was not very convincing as these fruits contain other nutrients that may have been the reason behind the positive difference. 


Reduces Inflammation


As you know, inflammation is your body’s way of reacting to infections, but it is common knowledge that things can go extreme. Inflammation is a precursor to many diseases and is as well culpable for developing complications in several illnesses. So, if there is any way to suppress inflammation, we should be looking at it.

A publication in the journal, Advances in Experimental Medicine and Biology, reported that strawberries have potent anti-inflammatory properties in animal models and cell culture significant to human diseases. This finding, alongside the other great properties of strawberries, is more than enough reason to take more strawberries then you already do.


Boosts Heart Health


Heart attack is one of the leading causes of death in America, and it is obviously caused by heart diseases. Fortunately, fisetin can help to keep the heart healthy in a couple of ways.

Researchers found that the antioxidants in fisetin can activate the genes associated with cell proliferation, thus fostering cardiac rehab. Studies to this effect have agreed that this will prevent ischemic damage, thus reducing the fatality of a heart attack.

There are also suggestions that fisetin reduces the risk of suffering a stroke. An animal model established that using fisetin along with Aspirin and quercetin led to a considerable extension of thrombin time and clotting time.


Promotion of Healthy Aging


Fisetin is senotherapeutic, meaning that it can prolong life and healthspan. Studies have found that fisetin can increase glutathione levels, a chief intracellular compound, and reduce oxidative stress. These two operations are sure to positively impact your health.

Fisetin can also suppress the secretion of pro-inflammatory molecules and activate crucial neurotrophic factors to support pathways that support survival, growth & healthy aging.


Final Words On Supplementing With Fisetin


Supplementing with fisetin is recommended to seniors as the plant pigment is mostly famous for its senolytic properties. However, this does not mean that other age groups can’t supplement with fisetin. Regardless of your age, you will get  a lot of benefits from regular consumption of cucumbers, apples, strawberries, and mangoes. 

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